abstract：:The purposes of this work are to: review the biological activities of Interleukin-2 (IL-2); evaluate the reported therapeutic benefits and toxicity of IL-2/lymphokine activated killer (LAK) cells; and project the role of IL-2/LAK cells in cancer therapy. Interleukin-2 is a glycoprotein lymphokine (mw 15,000) produced ...

journal_title：Annals of clinical and laboratory science

authors： Glassman AB

更新日期：1989-01-01 00:00:00

abstract：:Coronary heart disease (CHD), the leading cause of death in the western world, is multifactorial in nature. Abnormal lipoprotein levels are among the risk factors that cause atherosclerosis and, therefore, have been used as biochemical markers in assessing risk of developing CHD. The measurement of serum cholesterol, ...

journal_title：Annals of clinical and laboratory science

authors： Rifai N,Chapman JF,Silverman LM,Gwynnes JT

更新日期：1988-11-01 00:00:00

abstract：:The pyrrolizidine alkaloid monocrotaline produces pulmonary inflammation, hemorrhage, fibrosis, and hypertension. In rats, monocrotaline pneumotoxicity can be ameliorated by cotreatment with inhibitors of angiotensin converting enzyme (ACE), such as CL242817. In the present study, serum and urine copper (Cu) concentra...

journal_title：Annals of clinical and laboratory science

authors： Molteni A,Ward WF,Ts'ao CH,Fitzsimons EJ

更新日期：1988-11-01 00:00:00

abstract：:Certain DNA-binding proteins that regulate gene expression contain single or multiple copies of short polypeptide sequences, approximately 30 residues long, consisting of combinations of four Cys or His residues at defined spacing, so that Zn++ is complexed in tetrahedral coordination with the respective thiol-sulfur ...

journal_title：Annals of clinical and laboratory science

authors： Sunderman FW Jr,Barber AM

更新日期：1988-07-01 00:00:00

abstract：:The pathologic evaluation of hepatic changes secondary to drug ingestion is a difficult task because of the limited histologic response of the liver to hepatotoxins. The majority of these pharmacologic agents produce cholestasis, hepatitis, or both. Some drugs will produce damage if given for a sufficient time and in ...

journal_title：Annals of clinical and laboratory science

authors： Foulis PR,Sanford BH,Gottfried M

更新日期：1988-05-01 00:00:00

abstract：:Lead poisoning is an ancient and modern problem. Since many artists have had exposure to lead, it is appropriate to use some of their works as a vehicle to depict the symptoms of the variable syndromes associated with lead exposure. ...

journal_title：Annals of clinical and laboratory science

authors： Okulski E

更新日期：1988-03-01 00:00:00

abstract：:The erythrocyte abnormality most often associated with the toxic effects of commonly used drugs is premature destruction. The mechanisms of erythrocyte destruction include: denaturation of unstable hemoglobins, oxidation of sulfhydril groups in hemoglobin and the erythrocyte membrane in the presence of glucose-6-phosp...

journal_title：Annals of clinical and laboratory science

authors： Morse EE

更新日期：1988-01-01 00:00:00

abstract：:Neuropeptide modulation of hematopoietic stem cell differentiation was studied in an in vitro murine system. Endorphins were able to influence the erythropoietin-dependent differentiation of bone marrow cells into erythroid colony forming units in a dose dependent manner. The effects on progenitor cell maturation were...

journal_title：Annals of clinical and laboratory science

authors： Skelly RR,Fata J,Sharkis SJ,Sensenbrenner L,Ansari AA

更新日期：1987-09-01 00:00:00

abstract：:Variations in the level of prealbumin in serum and spinal fluid were noted on routine electrophoresis. Low serum levels were associated with infection, liver disorders, and malignant disease, whereas high levels were seen in inflammatory disorders. A high spinal fluid prealbumin was noted in a young child with a disse...

journal_title：Annals of clinical and laboratory science

authors： Salkie ML

更新日期：1987-09-01 00:00:00

abstract：:Prospective HLA-DR matching has been shown to enhance renal graft survival. It has also been demonstrated that the major stimuli in the one-way mixed lymphocyte culture reaction (MLR) are the DR rather than DQ class II histocompatibility antigens. A two antigen DR match between the potential recipient and donor is usu...

journal_title：Annals of clinical and laboratory science

authors： Smith RA,Belcher R

更新日期：1987-09-01 00:00:00

abstract：:A quality control program of analyses of toxic metals in urine has been carried out in the Nordic countries since 1978. In connection with these programs, the advantages and disadvantages of lyophilized compared to natural urine specimens as control materials have been investigated in three successive similar studies....

journal_title：Annals of clinical and laboratory science

authors： Valkonen S,Järvisalo J,Aitio A

更新日期：1987-05-01 00:00:00

abstract：:Human pituitary cells and pancreatic islet beta cells from surgical and autopsy material showed positive immunoreactivity to anti-porcine insulin antisera demonstrating the presence in these tissues of insulin or insulin-like immunoreactive material. Glutaraldehyde-fixed, one micron epoxy sections were used and the po...

journal_title：Annals of clinical and laboratory science

authors： Budd GC,Pansky B,Budd NJ

更新日期：1987-03-01 00:00:00

abstract：:The concentrations of progesterone, cortisol, estradiol, and transcortin binding capacity (TBC) were measured in plasma samples of women during normal pregnancy. Between 10 weeks and 20 weeks gestation, the mean of TBC increased linearly, and the mean increase in TBC for a given estradiol increment was constant until ...

journal_title：Annals of clinical and laboratory science

authors： Evans JJ,Sin IL,Duff GB,Frampton CM

更新日期：1987-03-01 00:00:00

abstract：:Interactions between human lymphocytes and target cells are highly variable. Lymphocytes may enter fibroblasts, establish cytoplasmic bridges, and draw material through these bridges from the fibroblasts; these lymphocytes may undergo divisions within the fibroblasts, while the fibroblasts vacuolize and die. In this i...

journal_title：Annals of clinical and laboratory science

authors： Sinkovics JG

更新日期：1986-11-01 00:00:00

abstract：:The radiation modifying effect and toxicity of tetraethylthiuram disulfide (disulfiram) have been studied. Disulfiram (DSM) inhibits aldehyde dehydrogenase, dopamine-beta-oxygenase, microsomal mixed-function oxidases and cytochrome P-450 enzymes. It is widely used for aversion therapy in alcoholism. Disulfiram also in...

journal_title：Annals of clinical and laboratory science

authors： Taylor RD,Maners AW,Salari H,Baker M,Walker EM Jr

更新日期：1986-11-01 00:00:00

abstract：:Retinal capillary basement membrane damage was demonstrated over a relatively short time period (two to three months) by feeding a diet containing high amounts of sucrose to spontaneously hypertensive rats (SHR) and their normotensive controls, Wistar Kyoto rats (WKY). Similar changes did not occur in SHR and WKY on a...

journal_title：Annals of clinical and laboratory science

authors： More NS,Rao NA,Preuss HG

更新日期：1986-09-01 00:00:00

abstract：:Screening programs using determinations of serum thyroxine have demonstrated that congenital hypothyroidism occurs in one in 4,000 live births in North America. More than 90 percent of affected infants have primary hypothyroidism with elevated plasma thyrotropin (TSH) levels. Since the feasibility of newborn screening...

journal_title：Annals of clinical and laboratory science

authors： Zeller WP,Sajous C,Ahmed GS,Anderson CL,Brooks M,Dobbins R

更新日期：1986-01-01 00:00:00

abstract：:A refined technique is described for the anatomical study of the heart and coronary arteries after perfusion with agar-barium sulfate contrast medium. The method includes dissection and isolation of the perfused coronary arteries with sequential cross-sectioning and radiography of intact and cross-sectioned vessels. T...

journal_title：Annals of clinical and laboratory science

authors： Giraldo AA,Higgins MJ,Humes JJ

更新日期：1986-01-01 00:00:00

abstract：:To define further the nature of the decreased responsiveness of neonatal neutrophils to chemotactic factor stimulation, neutrophil shape change induced by various concentrations of N-formyl-methionyl-leucyl-phenyl-alanine (fMLP) was studied using a whole blood assay. Samples from 48 full term neonates and paired healt...

journal_title：Annals of clinical and laboratory science

authors： Davis BH,Bronspiegel N,Krause PJ,Clark DA

更新日期：1985-11-01 00:00:00

abstract：:Adherence of 14C-glucose labeled Candida albicans to vaginal epithelial cells was measured in the presence of 10 potential inhibitory sugars at concentrations of 5 to 150 mg per ml for 90 minutes at 37 degrees C. In competitive inhibition experiments, no inhibition of adherence was seen with any sugar at any concentra...

journal_title：Annals of clinical and laboratory science

authors： Reinhart H,Muller G,Sobel JD

更新日期：1985-09-01 00:00:00

abstract：:Spurious macrocytosis in electronic cell counters has been associated with hyperglycemia. The increased mean corpuscular volume (MCV) is thought to be secondary to osmotic disequilibrium between the erythrocyte and the diluent used in the automatic cell counters. Employing three different hematology cell counters, the...

journal_title：Annals of clinical and laboratory science

authors： Planas AT,Van Voolen GA,Kelly LA

更新日期：1985-07-01 00:00:00

abstract：:A brief review of the literature precedes the presentation of a radiation behavioral teratology study. The various types of radiation and the units of measure used in radiation biology are discussed. The concept of the radiation-induced teratogenic "triad" of growth retardation, malformation, and death is presented. A...

journal_title：Annals of clinical and laboratory science

authors： Jensh RP

更新日期：1985-05-01 00:00:00

abstract：:Intraventricular hemorrhage (IVH) and classical periventricular leukomalacia complex are considered the two most common forms of perinatal anoxic-ischemic brain injury. However, recently, a third entity, the periventricular leukomalacia complex (PLC) was described and was seen in 31 percent of 61 premature infants com...

journal_title：Annals of clinical and laboratory science

authors： Grunnet ML,Conard FU

更新日期：1985-03-01 00:00:00

abstract：:A case of a 40 year-old woman with Hodgkin's disease who developed acute non-lymphocytic leukemia (ANLL) accompanied by several abnormal chromosomal findings is illustrated. A very unusual coincidental finding was the coexistence of Hodgkin's lymphoma and ANLL in the same lymph node. ...

journal_title：Annals of clinical and laboratory science

authors： Silberman S,Messmore HL Jr

更新日期：1985-01-01 00:00:00

abstract：:Absorbed lead continuously adds to the lead deposited in the vascularized circumpulpal dentin of the teeth. Thus, this dental tissue is expected to contain a lead concentration which reflects the integrated lead exposure during the time from completion of tooth formation to tooth extraction or shedding. A method has b...

journal_title：Annals of clinical and laboratory science

authors： Grandjean P,Hansen ON,Lyngbye K

更新日期：1984-07-01 00:00:00

abstract：:The existence of clonorchiasis cases among the Asian immigrants and the major clinical and pathologic features encountered in those patients is emphasized. Owing to the longevity of the parasite, clinical symptoms may occur long after endemic exposure. The common manifestations among the immigrants are recurrent pyoge...

journal_title：Annals of clinical and laboratory science

authors： Sun T

更新日期：1984-05-01 00:00:00

abstract：:The detection of oligoclonal bands of IgG in cerebrospinal fluid by isoelectric focusing is a useful aid in the diagnosis of multiple sclerosis. At present, this test is performed on polyacrylamide gels which are technically very difficult to prepare and are not suitable for the routine laboratory. A technique is desc...

journal_title：Annals of clinical and laboratory science

authors： Lane JR,Bowles KJ,Normansell DE

更新日期：1984-03-01 00:00:00

abstract：:Ultrastructural studies with the transmission (TEM) and scanning (SEM) electron microscopes have added greatly to our knowledge of cellular structure and function in the liver. The normal polyhedral hepatocyte has numerous subcellular organelles, such as mitochondria, peroxisomes, lysosomes and complex rough (rer) and...

journal_title：Annals of clinical and laboratory science

authors： Goldblatt PJ,Gunning WT 3rd

更新日期：1984-03-01 00:00:00

abstract：:Lymphocytes from rheumatoid arthritis patients have been fused with drug-marked human myeloma cell lines and hybrids selected which secrete rheumatoid factors. Limiting dilution and soft agarose plates have been used to clone these hybrids, but so far stable clones have not been obtained. Epstein-Barr virus has been u...

journal_title：Annals of clinical and laboratory science

authors： Normansell DE,Lane JR

更新日期：1984-01-01 00:00:00

abstract：:The sequence of contraction-relaxation for myocardial cells is believed to be linked to Ca2+ flux across the sarcoplasmic reticulum. Alterations of sarcoplasmic reticulum function during ischemia may result in depressing the myocardial contraction-relaxation sequence. This study examines the relationship between the m...

journal_title：Annals of clinical and laboratory science

authors： Peng CF,Straub KD,Murphy ML

更新日期：1983-11-01 00:00:00

abstract：:Glycosylated hemoglobin (HbA1c) levels on blood obtained from 28 cadavers were compared with that of healthy volunteers and patients with diabetes mellitus. Levels of HbA1c did not correlate with post-mortem intervals of four to 36 hours, suggesting that HbA1c is stable under these conditions. All deceased with a hist...

journal_title：Annals of clinical and laboratory science

authors： Chen C,Glagov S,Mako M,Rochman H,Rubenstein AH

更新日期：1983-09-01 00:00:00

abstract：:The determination of the T and B subpopulation percentages and lymphocyte blastogenic response functions are useful tools to evaluate and monitor disorders associated with immunodeficiencies, lymphoproliferations, malignancies, infections, inflammations, and autoimmune diseases. Comparative studies of cryopreserved ly...

journal_title：Annals of clinical and laboratory science

authors： Liu SS,Liu PI,Daniel SJ

更新日期：1983-07-01 00:00:00

abstract：:A diagnosis of prolymphocytic leukemia was made from the blood and bone marrow of a 50 year old man. The neoplastic cells were studied by use of light and electron microscopy. Neoplastic cells were focally positive for acid phosphatase and alpha naphthyl acetate esterase. In addition, neoplastic cells formed rosettes ...

journal_title：Annals of clinical and laboratory science

authors： Planas AT,Zamkoff KW,Poiesz BJ,Kurec AS,Davey FR

更新日期：1983-05-01 00:00:00

abstract：:Recently documented Vibrio cholerae and non-cholera vibrio infections in Florida and other American waters led to a study to determine the selectivity of thiosulfate-citrate-bile salts-sucrose media (TCBS). Thirty-one species with 188 different strains of clinical, marine, and stock origin were examined on the TCBS me...

journal_title：Annals of clinical and laboratory science

authors： Lotz MJ,Tamplin ML,Rodrick GE

更新日期：1983-01-01 00:00:00

abstract：:The case is described of a low birth weight infant who developed severe neutropenia, thrombocytopenia and monocytosis in the course of staphylococcal septicemia. Light microscopy examination of the blood revealed bacteria inside the monocytes. On electron microscopy, the monocytes were degranulated and distorted by th...

journal_title：Annals of clinical and laboratory science

authors： Coppola A,Rao S

更新日期：1982-11-01 00:00:00

abstract：:While there is no single best procedure for performing prenatal diagnosis, ther is a rationale or strategy which will produce correct, reliable results. The investigator should be experienced with all the tests and know what to expect from each. At least two of these tests should e used (more if there s ambiguity) on ...

journal_title：Annals of clinical and laboratory science

authors： Grebner EE,Jackson LG

更新日期：1982-09-01 00:00:00

abstract：:Infection resulting in transient reticulocytopenia and anemia, the so called "aplastic crisis," has frequently been documented in patients with congenital hemolytic anemia. However, this association with hematologically normal patients has been less well recognized. Its occasional severity is illustrated by this repor...

journal_title：Annals of clinical and laboratory science

authors： Biemer JJ,Taylor FM 3rd

更新日期：1982-05-01 00:00:00

abstract：:The pattern of excretion of urinary acid mucopolysaccharides (AMPS) has been helpful to establish the diagnosis of mucopolysaccharidoses. The importance of urine analysis for AMPS and the specific enzyme assays is exemplified in a 3 1/2 year old Caucasian male with severe mental retardation, small stature, thoracolumb...

journal_title：Annals of clinical and laboratory science

authors： Matalon R,Wappner R,Deanching M,Brandt IK,Horwitz A

更新日期：1982-05-01 00:00:00

abstract：:Utilizing fetal electrocardiography, ultrasound, M-mode and two dimensional echocardiography, fetal cardiac function, structure, and rhythm were studied in pregnancies with obstetrical risk factors. Risk factors for fetal cardiac abnormalities were defined to include: maternal diabetes, connective tissue disorders; Rh...

journal_title：Annals of clinical and laboratory science

authors： Crawford CS

更新日期：1982-03-01 00:00:00

abstract：:Although it is widely accepted that patients with immune thrombocytopenia produce platelet antibodies, the demonstration of such antibodies has been difficult and time consuming. A simple and quick enzyme linked immunoassay for platelet antibodies is presented. The platelet associated IgG is coupled with alkaline phos...

journal_title：Annals of clinical and laboratory science

authors： Saleem A,Banez EI,Sitters B

更新日期：1982-01-01 00:00:00